ZETA 1. is indicated for the spatial positioning and orientation of neurosurgical instruments used by surgeons. The device is indicated only for cranial surgery where reference to a rigid anatomical structure can be identified, does not require rigid fixation of the patient, and does not require fixation of a navigated instrument guide to the patient. The system is intended to be used in operating rooms and in less acute surgical settings such as interventional procedure suites. The use of the ZETA Cranial Navigation System for ventriculostomy, brain biopsy and transcranial magnetic stimulation require separate compatible instruments and accessories. ©️ 2025 ZETA Surgical Inc. All rights reserved. Unless otherwise specified, all product and service names appearing in this Internet site are trademarks owned by or licensed to ZETA Surgical, its subsidiaries or affiliates. No use of any ZETA Surgical trademark, trade name, or trade dress in this site may be made without the prior written authorization of ZETA Surgical, except to identify the product or services of the company.
PRECISION BEYOND THE OR
navigation for every case, supercharged with ai
Real–time image–guided navigation
Live, continuous surgical guidance tracking patient movement 20 times per second
Submilimeter accuracy without head fixation
ZETA ensures pinpoint precision without cranial pins or general anesthesia, enhancing safety and outcomes
Adaptable to any clinical environment
Compact, mobile, and fast to deploy — ZETA performs in operating rooms, emergency settings, and ambulatory centers
MEET THE SYSTEM
One cart, rapid deployment
ULTRA—FAST SETUP
Deploy ZETA in under 5 minutes — no pins, clamps, or anesthesia required.
AI IMAGE ANALYSIS
ZETA's AI engine ingests standard CT and MRI scans and constructs a high-resolution 3D head model.
MARKERLESS
REGISTRATION
Our RealTrack™ technology aligns real-time camera capture with a constructed model and continuosly adjusts to patient movement.
CLINICAL DASHBOARD WITH REAL—TIME GUIDANCE
Navigation interface displays surgical instrument's trajectory in real-time against patient internal anatomy and measures accuracy metrics.
Our platform creates game–changing impact for a wide range of minimally–invasice and non–invasive procedures.
USE CASES
Ventriculostomy
In our breakthrough clinical study, ZETA helped surgeons achieve exceptional accuracy in bedside external ventricular drain cases.
100% single-pass catheter placement (vs 81% freehand).
100% ideal placement (vs 32% feehand).
0% adverse events (vs 28% freehand).
0% revision surgeries (vs 19% freehand).
Brain Biopsy
By eliminating the need for skull fixation and anesthesia, ZETA makes bedside brain biopsy a possibility, freeing up OR resources and improving surgery efficiency.
>2h estimated saving in procedure time.
Transcranial Magnetic Stimulation
ZETA brings neurosurgical level accuracy to TMS therapy, enabling clinicians to repeatedly target a precise point across sessions and improve treatment efficiency.
<1mm positional accuracy.
<1° angular accuracy.
*Releasing Fall 2025
Tumor Resection
Zeta allows for tumor resections such as cavernoma resections to be performed without cranial skull fixation, in settings such as ambulatory surgical centers.
<1h estimated time to perform a cavernoma resection
We improve neurosurgeries for patients, hospitals, and surgeons
PATIENT impact
<5-minute system deployment with no skull fixation required, enabling deployment in virtually any operative setting, including emergency rooms and ambulatory centers.
100% single-pass accuracy of EVD catheter placement in a multi-center study – eliminating the need for catheter revisions and reducing the risk of ventriculostomy-related infection.
Reduces the risk of post-operative pulmonary complications and injuries associated with skull fixation in cranial procedures.
STAFFING IMPACT
No anesthesiologist or surgical tech required, thanks to a simplified workflow.
Patients can bypass Phase I PACU for procedures such as brain biopsy, reducing nursing hours and post-op care resources.
Reduces reliance on neuro-OR scrub nurses and radiology techs by taking cranial surgeries outside of the OR, easing staffing bottlenecks.
FINANCIAL IMPACT
Saves $2,150–$2,628 per EVD by avoiding costly catheter replacements and infection treatment.
Reduces $1,800 in variable OR costs per brain biopsy by minimizing procedure time.
Moving procedures such as brain biopsy cases away from neuro OR enables additional OR surgeries with up to $9,000 contribution margin per case — totaling $1.4M/year in added value for 200 annual cases.
WORKFLOW
Reduces procedure time from 5 hours to <3 hours for brain biopsies, improving case throughput.
Enables procedures outside the OR, freeing up premium surgical time for complex cases.
Submillimeter precision maintained in cranial procedures in real time even with rapid patient movement.
BACKED BY LEADING NEUROSURGEONS
DR. WILLIAM GORMLEY
Director
Neurosurgical innovation, brigham and women's hospital
Neurosurgical innovation, brigham and women's hospital
co-director
crushing neurosurgical outcomes center
crushing neurosurgical outcomes center
associate professor
harvard medical school
harvard medical school
ZETA Co-founder
DR. ELAD LEVY
FORMER national director
american board of neurological surgery
american board of neurological surgery
co-director
gates stroke center at kaleida health
gates stroke center at kaleida health
professor and chairman of neurosurgery
University of Buffalo
University of Buffalo
zeta advisor
DR. AIMEE DEGAETANO
Former Global Vice President
Viz.ai
Viz.ai
zeta advisor
DR. BRIAN NAHED
NEUROSURGICAL ONCOLOGIST
MASSACHUSETTS GENERAL HOSPITAL
MASSACHUSETTS GENERAL HOSPITAL
assistant PROFESSOR
HARVARD MEDICAL SCHOOL
HARVARD MEDICAL SCHOOL
EXECUTIVE member
CONGRESS OF NEUROLOGICAL SURGEONS AND AMERICAN ASSOCIATION OF NEUROLOgical surgeons
CONGRESS OF NEUROLOGICAL SURGEONS AND AMERICAN ASSOCIATION OF NEUROLOgical surgeons
zeta advisor
DR. KYLE WU
Neurosurgical oncologist
Wexner Medical Center
Wexner Medical Center
assistant PROFESSOR
ohio state university wexner medical center
ohio state university wexner medical center
zeta advisor
DR. Chengyuan Wu
Chief of Epilepsy and Neuromodulation Neurosurgery
Jefferson Health
Jefferson Health
Professor
Thomas Jefferson University
Thomas Jefferson University
zeta advisor
Dr. Faith Robertson
Neurosurgery Fellow
Massachusetts General Hospital
Massachusetts General Hospital
zeta advisor
DR. REES COSGROVE
FORMER CHIEF OF FUNCTIONAL NEUROSURGERY
BRIGHAM AND WOMEN´S HOSPITAL
BRIGHAM AND WOMEN´S HOSPITAL
PRESIDENT
US AND WORLD SOCIETY OF FUNCTIONAL NEUROSURGERY
US AND WORLD SOCIETY OF FUNCTIONAL NEUROSURGERY
zeta advisor
DR. MATTHEW MCGIRT
CHIEF OF SPINE
Atrium university hospital
Atrium university hospital
director of value-based contracting
carolina neurosurgery & spline associates
carolina neurosurgery & spline associates
zeta advisor
Research partners
PUBLICATIONS
Jun 2025
Zeta Surgical, Harvard Medical School, Brigham and Women’s Hospital, University of Cambridge
High-Accuracy Real-Time Navigation for Transcranial Magnetic Stimulation
Dec 2024
Zeta Surgical, SingHealth Duke-NUS, National Neuroscience Institute, Harvard Medical School
Real-time vision-based navigation for precision neurosurgery: a first-in-human ventriculostomy study
Nov 2024
Zeta Surgical, Harvard Medical School, Brigham and Women's Hospital, Imperial College London
SCOUT: Skull-Corrected Optimization for Ultrasound Transducers
Nov 2023
Zeta Surgical, Harvard Medical School, Masschusetts General Hospital, Brigham and Women's Hospital
High-Accuracy Neuro-Navigation with Computer Vision for Frameless Registration and Real-Time Tracking.
Jun 2022
Zeta Surgical, Harvard Medical School, Brigham and Women's Hospital, SingHealth Duke-NUS, National Neuroscience Institute
Stereotactic Neurosurgical Robotics With Real-Time Patient Tracking: A Cadaveric Study
Oct 2021
Zeta Surgical, Harvard Medical School, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard John A. Paulson School of Engineering and Applied Sciences, SingHealth Duke-NUS, National Neuroscience Institute
Frameless neuronavigation with computer vision and real-time tracking for bedside external ventricular drain placement: a cadaveric study
Design awards
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